Christians receive comin Diskussionen Allgemein über die Kryptowelt 24.12.2018 08:01
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CHICAGO, Nov. 28 (Xinhua) -- Researchers at the University of Illinois (UI) are trying to use tiny drug-laden nanoparticles to seek and destroy cancer stem cells.
They used the nanoparticles to deliver niclosamide that targets a protein called CD44 only appearing on the surface of cancer stem cells, and found the cancer stem cells lost their stemlike properties after treatment with the niclosamide-bearing targeted nanoparticles, and are less able to cause the cancer to recur or metastasize.
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"I call them 'GPS-enabled nanoparticles,' because they seek out only the cells that have cancer stem cell properties. Then they latch onto the cells and deliver the drug," said Dipanjan Pan, a UI professor of bioengineering. "To the best of our knowledge, this is the first demonstration of delivering cancer stem-cell-targeted therapy with a nanoparticle."
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Previous study found that niclosamide works on a particular gene-regulation pathway in cancer stem cells. Niclosamide is on the World Health Organization's List of Essential Medicines, which is an index of the safest and most effective drugs in the world, and is a drug commonly prescribed to treat tapeworm infections.
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UI researchers are now working to create a combination therapy that can deliver drugs for the primary cancer, such as traditional chemotherapies, as well as targeted agents that can treat cancer stem cells. They are also testing the nanoparticle drug-delivery system in large animal models to bring it a step closer to the clinic.
The study has been published in the journal Molecular Cancer Therapeutics.
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As a young man, Bidhan Kamol Rosario left his Catholic village to fight for Bangladesh's independence. Now he questions his future in the country after a rise in Islamist extremism that has left minorities living in fear.
As Bangladesh's small Catholic community eagerly awaits the first visit by a pope in more than 30 years, many say it has never been more difficult to practice their faith in the Muslim-majority country.
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